And I will put enmity between thee and the woman, and between thy seed and her Seed; He shall bruise thy head, and thou shalt bruise His heel. – Genesis 3:15

That first news of the coming Champion came at a time when all man’s pleas were failures. Adam had thrown the blame on Eve-“The woman whom Thou gavest to be with me, she gave me of the tree, and I did eat.” Eve had also thrown the blame on the serpent; but the Lord God had silenced all such excuses, and driven them from their refuges. He had made them feel their guilt, and had pronounced upon them the inevitable sentence; and then it was that He spake of the “Seed of the woman.” Here was man’s first, and last, and best hope. So too, my friend, when you dare no longer plead your innocence, nor mention extenuations and excuses, then Jesus comes in. If conscience oppresses you so sorely that you cannot escape from it; if it be so that all you can say is “Guilty; willfully guilty,” then Jesus comes. If you neither blame your surroundings, nor your companions, nor the providence of God, nor our physical weakness, nor anything else, but just take all the blame to yourself because you cannot help doing so, then Jesus comes in. Verily you have sinned against God, against your parents, against your fellowmen, against light, against knowledge, against conscience, and against the Holy Ghost; no wonder, therefore, that you stand speechless, unable to offer any plea by way of self-justification. It is in that moment of shame and confusion that the Savior says, “Lo, I come.” For such as you are He is an Advocate. When a sinner cannot plead for himself, Christ pleads for him; when his excuses have come to an end, then will the Lord put away his sin through His own great sacrifice. Is not this a precious gospel word? ~ C.H. Spurgeon

https://www.blueletterbible.org/Comm/spurgeon_charles/sermons/2203.cfm