And I will put enmity between thee and the woman… -Genesis 3:15

Do you recollect how you were led to see the bruising of Christ’s heel and to stand in wonder and observe what the enmity of the serpent had wrought in Him? Did you not begin to feel the bruised heel yourself? Did not sin torment you? Did not the very thought of it vex you? Did not your own heart become a plague to you? Did not Satan begin to tempt you? Did he not inject blasphemous thoughts, and urge you on to desperate measures; did he not teach you to doubt the existence of God, and the mercy of God, and the possibility of your salvation, and so on? This was his nibbling at your heel. He is at his old tricks still…

Did not your worldly friends begin to annoy you? Did they not give you the cold shoulder because they saw something about you so strange and foreign to their tastes? Did they not impute your conduct to fanaticism, pride, obstinacy, bigotry, and the like? Ah, this persecution is the serpent’s seed beginning to discover the woman’s Seed, and to carry on the old war. What does Paul say? “But as then he that was born after the flesh persecuted him that was born after the Spirit, even so it is now.” True godliness is an unnatural and strange thing to them and they cannot away with it Though there are no stakes in Smithfield, nor racks in the Tower, yet the enmity of the human heart towards Christ and His Seed is just the same, and very often shows itself in “trials of cruel mockings” which to the tender hearts are very hard to bear. Well, this is your heel being bruised in sympathy with the bruising of the heel of the glorious Seed of the woman. ~ C.H. Spurgeon

https://www.blueletterbible.org/Comm/spurgeon_charles/sermons/1326.cfm