For when we were yet without strength, in due time Christ died for the ungodly. – Romans 5:6

…and with His stripes we are healed. – Isaiah 53:5

Friends, sin is a disease because it weakens the moral energy, just as many diseases weaken the sick person’s body. A man under the influence of some particular disease becomes quite incapacitated for his ordinary work…How often is a strong man brought down to utter helplessness! He who used to run like a hare must now be led out if he is to breathe the fresh air of Heaven. He who once could cut with the axe, or pound with the hammer, must now be lifted and carried like a child. You all know how greatly the body is weakened by disease—and just so is it with sin and the spirit. Sin takes away from the soul all power. Does not the Apostle speak of us as being, “without strength” when, “in due time Christ died for the ungodly”? The man has not the power or the will to believe in Christ, but yet he can believe a lie most readily! And he has no difficulty in cheating himself into self-conceit. The man has not the strength to quit his sin, though he has power to pursue it with yet greater energy! He is weak in the knees so that he cannot pray. He is weak in the eyes so that he cannot see Jesus as his Savior. He is weak in the feet so that he cannot draw near to God. He has withered hands, dumb lips, deaf ears and he is palsied in his whole system! O Sin, you take away from man the strength he needs with which to make the pilgrimage to Heaven, or to go forth to war in the name of the Lord of Hosts! Sin does all this and yet men love it and will not turn from it to Him who alone can destroy its deadly power…Oh, what an awful mass of disease there is all round us in these streets and in these myriads of houses! Sin has done for mankind the most dreadful deeds—it is the direst of all calamities, the worst of all infections!

“With His stripes we are healed.” This is not a temporary remedy—it is a medicine which, when it once gets into the soul, breeds therein health that shall make that soul perfectly whole, so that at last, among the holy ones before the Throne of God on high, that man shall sing with all his fellows— “With His stripes we are healed.” Glory be to the bleeding Christ! All honor, majesty, dominion and praise be unto Him forever and ever!” And let all the healed ones say, “Amen, and Amen.” ~ C.H. Spurgeon

https://www.blueletterbible.org/comm/spurgeon_charles/sermons/2499.cfm