They gave Me also gall for My meat; and in My thirst they gave Me vinegar to drink. – Psalm 69:21

They gave Him vinegar to drink mingled with gall: and when He had tasted thereof, He would not drink. – Matthew 27:34

According to modern thought man is a very fine and noble creature, struggling to become better. He is greatly to be commended and admired, for his sin is said to be seeking after God, and his superstition is a struggling after light. Great and worshipful being that he is, truth is to be altered for him, the gospel is to be modulated to suit the tone of his various generations, and all the arrangements of the universe are to be rendered subservient to his interests. Justice must fly the field lest it be severe to so deserving a being; as for punishment, it must not be whispered to his ears polite. In fact, the tendency is to exalt man above God and give him the highest place. But such is not the truthful estimate of man according to the Scriptures: there man is a fallen creature, with a carnal mind which cannot be reconciled to God; a worse than brutish creature, rendering evil for good, and treating his God with vile ingratitude. Alas, man is the slave and the dupe of Satan, and a black-hearted traitor to his God. Did not the prophecies say that man would give to his incarnate God gall to eat and vinegar to drink? It is done. He came to save, and man denied Him hospitality: at the first there was no room for Him at the inn, and at the last there was not one cool cup of water for Him to drink; but when He thirsted they gave Him vinegar to drink. This is man’s treatment of his Saviour. Universal manhood, left to itself, rejects, crucifies, and mocks the Christ of God… See how man at his best mingles admiration of the Saviour’s person with scorn of His claims; writing books to hold Him up as an example and at the same moment rejecting His deity; admitting that He was a wonderful man, but denying His most sacred mission; extolling His ethical teaching and then trampling on His blood: thus giving Him drink, but that drink vinegar. O my hearers, beware of praising Jesus and denying His atoning sacrifice. Beware of rendering Him homage and dishonouring His name at the same time. ~ C.H. Spurgeon

https://www.blueletterbible.org/comm/spurgeon_charles/sermons/1409.cfm