But He was wounded for our transgressions, He was bruised for our iniquities: the chastisement of our peace was upon Him; and with His stripes we are healed…the LORD hath laid on Him the iniquity of us all. – Isaiah 53:5,6

Sin was made to meet upon the suffering person of the innocent substitute. I have said “the suffering person” because the connection of the text requires it. “He was wounded for our transgressions, He was bruised for our iniquities; the chastisement of our peace was upon Him, and with His stripes we are healed.” It is in connection with this, and as an explanation of all His grief, that it is added, “The Lord hath laid on Him the iniquity of us all.” The Lord Jesus Christ would have been incapable of receiving the sin of all His people as their substitute had He been Himself a sinner; but He was, as to His divine nature, worthy to be hymned as “Holy, Holy, Holy, Lord God of Sabaoth;” and, as to His human nature, He was, by miraculous conception, free from all original sin, and in the holiness of His life He was such that He was the Lamb of God, without spot, or wrinkle, or any such thing, and therefore He was on all accounts capable of standing in the room, place, and stead of sinful men. The doctrine of the text is, that Jesus Christ, who was man of the substance of his mother, and who was, nevertheless, very God of very God, most true and glorious Creator, Preserver, did stand in such a position as to take upon Himself the iniquity of all His people, remaining still Himself innocent; having no personal sin, being incapable of any, but yet taking the sin of others upon Himself…”For He hath made Him to be sin for us who knew no sin, that we might be made the righteousness of God in Him.” ~ C.H. Spurgeon

https://www.blueletterbible.org/Comm/spurgeon_charles/sermons/0694.cfm