…and thou shalt bruise His heel. -Genesis 3:15 

You know how all His life long His heel, that is, His lower part, His human nature, was perpetually being made to suffer. He carried our sicknesses and sorrows. But the bruising came mainly when both in body and in mind His whole human nature was made to agonize; when His soul was exceeding sorrowful even unto death, and His enemies pierced His hands and His feet, and He endured the shame and pain of death by crucifixion. Look at your Master and your King upon the cross, all disdained with blood and dust! There was His heel most cruelly bruised. When they take down that precious body and wrap it in fair white linen and in spices, and lay it in Joseph’s tomb, they weep as they handle the casket in which the Deity had dwelt, for there again Satan had bruised His heel. It was not merely that God had bruised Him, “though it pleased the Father to bruise Him,” but the devil had let loose Herod, and Pilate, and Caiaphas, and the Jews, and the Romans, all of them his tools, upon Him whom he knew to be the Christ, so that He was bruised of the old serpent. That is all, however! It is only His heel, not His head, which is bruised! For lo, the Champion rises again; the bruise was not mortal nor continual. Though He dies, yet still so brief is the interval in which He slumbers in the tomb that His holy body hath not seen corruption, and He comes forth perfect and lovely in His manhood, rising from His grave as from a refreshing sleep after so long a day of unresting toil! Oh the triumph of that hour! As Jacob only halted on his thigh when he overcame the angel, so did Jesus only retain a scar in His heel, and that He bears to the skies as His glory and beauty. Before the throne He looks like a lamb that has been slain, but in the power of an endless life He liveth unto God. ~ C.H. Spurgeon

https://www.blueletterbible.org/Comm/spurgeon_charles/sermons/1326.cfm